BNT162b2 LP.8.1 early vaccine effectiveness against COVID-19 emergency department, urgent care, and outpatient visits - PubMed
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- The BNT162b2 LP.8.1-adapted COVID-19 vaccine demonstrated early effectiveness against mild-to-moderate COVID-19 during the 2025-2026 respiratory virus season.
- Vaccine effectiveness (VE) was 57% against emergency department/urgent care visits and 54% against outpatient visits, based on a test-negative case-control study in the US Veterans Affairs Healthcare System.
- The study included adult patients with acute respiratory infection who were tested for SARS-CoV-2 from September 10 to November 30, 2025, with 10.7% of episodes being COVID-19 cases.
- Results support the continued importance of COVID-19 vaccination for recommended populations and inform clinical decision-making.