Global translational and metabolic remodeling during iron deprivation in Toxoplasma gondii - PubMed
21 hours ago
- #Toxoplasma gondii
- #Metabolic Remodeling
- #Iron Metabolism
- Iron deprivation in Toxoplasma gondii triggers swift translational repression and proteome remodeling, even before decreases in the key translational factor ABCE1.
- Iron depletion alters mitochondrial morphology, reduces mitochondrial respiration, and rewires energy metabolism, with an increased reliance on glycolysis for energy generation.
- Metabolomics show accumulation of glycolysis and TCA cycle intermediates, and stable isotope labeling reveals a disconnect between these pathways under iron deprivation.
- Parasites become highly dependent on glucose as a carbon source during iron restriction, and limiting glucose availability increases sensitivity to iron deprivation.
- Limiting glutamine metabolism improves parasite fitness in iron-depleted conditions, highlighting metabolic flexibility for survival under nutrient stress.