Levetiracetam for Seizure Prophylaxis after Traumatic Brain Injury: A Severity-Stratified Cohort Study of 51,000 Patients - PubMed
5 hours ago
- #Traumatic Brain Injury
- #Levetiracetam
- #Seizure Prophylaxis
- Levetiracetam prophylaxis reduced early epilepsy (within 7 days) in severe TBI patients, but not in mild TBI.
- It did not reduce late epilepsy (within 1 year) in either mild or severe TBI patients.
- Adverse effects of levetiracetam included memory impairment, metabolic disorders, and psychiatric symptoms.
- Routine prophylaxis should be limited to severe TBI or high-risk patients due to adverse effects and limited long-term protection.
- Study suggests re-evaluation of current seizure prophylaxis guidelines based on newer, large-scale real-world data.