The immunology of human breast cancer - PubMed
a day ago
- #Immunotherapy
- #Breast Cancer Immunology
- #Immune Checkpoint Inhibitors
- Immunotherapy with immune checkpoint inhibitors (ICIs) has transformed treatment for some solid cancers like melanoma and lung carcinoma.
- Breast cancers, especially hormone receptor-positive types, generally respond poorly to ICIs due to low immunogenicity and an immunosuppressive microenvironment.
- Key barriers to effective immunotherapy in breast cancer include tumor-intrinsic factors and microenvironmental immunosuppression.
- Triple-negative breast cancer is an exception, showing better responsiveness to ICIs compared to other subtypes.
- Understanding the interplay between breast cancer, hormonal regulation, and the immune system is crucial for advancing immunotherapy in this disease.