Weight Regain Reverses Caloric Restriction-Induced Benefits on the Insulin-IGF-1 Nutrient-Sensing Pathway: Post Hoc Analysis From the CALERIE-2 Randomized Controlled Trial - PubMed
7 hours ago
- #biological aging
- #insulin resistance
- #caloric restriction
- The study investigates the long-term metabolic effects of sustained weight loss versus weight regain after caloric restriction (CR).
- Participants in the CALERIE-2 trial were randomized to 25% CR or control diet, with weight loss targeted over 6-12 months followed by a maintenance phase.
- Weight regain (>5% of baseline) reversed improvements in insulin sensitivity and IGF-1-related markers, negating CR benefits.
- Sustained weight loss maintained metabolic benefits and was associated with reduced biological age.
- The findings suggest that maintaining moderate weight loss is more effective for improving insulin resistance and hormonal profiles linked to diabetes risk and aging.