NKG2A inhibition promotes NK cell-CD8+ T cell interactions to improve anticancer immunity in ovarian carcinoma - PubMed
5 hours ago
- #ovarian cancer
- #NKG2A inhibition
- #immune checkpoint
- NK cell functionality varies across cancers; NSCLC has functional NK cells, while HGSOC has dysfunctional NK cells expressing NKG2A.
- NK and CD8+ T cells interact critically in HGSOC; depleting either impairs the other, affecting antitumor immunity.
- Blocking NKG2A restores NK cell cytotoxicity and enhances CD8+ T cell responses, improving PD-1 blockade efficacy in HGSOC models.
- The NKG2A-HLA-E axis is a clinically actionable immune checkpoint in tumors with impaired NK cell functions.