Prevalence, Antimicrobial Susceptibility, and Molecular Characteristics of Ceftazidime-Avibactam-Resistant Klebsiella pneumoniae in a Chinese Hospital - PubMed
2 days ago
- #Antimicrobial Resistance
- #Klebsiella pneumoniae
- #Ceftazidime-Avibactam
- Study focused on ceftazidime-avibactam-resistant Klebsiella pneumoniae (CRKPCZA-R) in a Chinese hospital.
- 67 out of 623 CRKP isolates (10.8%) were CRKPCZA-R, with high susceptibility to aztreonam-avibactam, cefiderocol, polymyxin B, and tigecycline.
- Most prevalent resistance gene was bla NDM-1 (44.8%), followed by bla IMP-4 (9.0%), bla NDM-5 (7.5%), and bla NDM-4 (1.5%).
- 37.3% of CRKPCZA-R isolates co-harbored more than two carbapenemase-encoding genes, mainly bla NDM-1 and bla KPC-2 (31.3%).
- Enzyme inhibitor enhancement method detected carbapenemase activity effectively, except for isolates with multiple carbapenemases.
- 21 KL64-ST11 CRKPCZA-R isolates had bla NDM-1, bla KPC-2, and ompk36 deletion, with 17 co-harboring high virulence gene markers.
- Patients infected with these 21 isolates were older and had more serious illnesses, requiring closer monitoring.