Cerebrospinal fluid and plasma metabolites in Parkinson's disease: a Mendelian randomization study - PubMed
5 hours ago
- #Parkinson's disease
- #Mendelian randomization
- #Metabolomics
- The study investigates causal relationships between cerebrospinal fluid (CSF) and plasma metabolites and Parkinson's disease (PD) risk using Mendelian Randomization (MR) analysis.
- Six CSF metabolites showed suggestive causal relationships with PD, including dimethylglycine, gluconate, oxalate, and unknown metabolites X-12015 (positive associations), and (1-enyl-palmitoyl)-2-arachidonoyl-GPC (P-16:0/20:4) and X-23587 (negative associations).
- Forty-nine plasma metabolites demonstrated suggestive causal relationships with PD, with key metabolites like hydroxy-CMPF, carnitine C14, and 1-dihomo-linolenylglycerol (20:3) showing positive associations, and tryptophan, succinate to acetoacetate ratio, and O-sulfo-L-tyrosine showing negative associations.
- O-sulfo-L-tyrosine emerged as the most significant protective metabolite in plasma, showing robust associations across multiple MR models.
- The findings highlight potential biomarkers and therapeutic targets for PD, providing a foundation for further exploration of metabolic pathways in PD pathogenesis.