The Yin-Yang balance of SIRT1 and SIRT2 in cancer metabolic remodeling - PubMed
2 days ago
- #SIRT1-SIRT2
- #Cancer Metabolism
- #Therapeutic Strategies
- SIRT1 and SIRT2 are NAD+-dependent deacetylases regulating cancer metabolic stress.
- They modulate glucose, lipid, mitochondrial metabolism, and immune responses in tumors.
- Their opposing activities create a Yin-Yang balance in cancer metabolism.
- Autophagy is a key node regulated by both SIRT1 and SIRT2, linking nutrient sensing and stress adaptation.
- SIRT2 acts as a metabolic checkpoint, restraining CD8+ T cell effector metabolism.
- Therapeutic strategies targeting SIRT1 and SIRT2 balance could reprogram cancer metabolism.
- Combining SIRT2 inhibition with immune checkpoint blockade is a potential treatment approach.