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Why Do Most People Quit Ozempic After Two Years?
a year ago
- Weight-loss drugs like semaglutide (Wegovy) are popular but require indefinite use for sustained effectiveness.
- A JAMA study found most people quit these drugs within two years, leading to weight regain and loss of health benefits.
- GLP-1 receptor agonists (e.g., semaglutide, Ozempic) promote weight loss and improve cardiometabolic health but benefits reverse upon discontinuation.
- Set point theory suggests the body resists weight loss by increasing appetite and reducing calorie burn.
- Clinical trials show weight regain after stopping GLP-1 drugs, though some modest health benefits may persist.
- Insurance coverage and high costs ($1,000/month) are major barriers to continued use, especially for non-diabetic patients.
- Stigma around obesity and weight-loss drugs may influence discontinuation rates.
- Researchers are exploring dosage tapering to maintain weight loss without indefinite treatment.
New obesity drugs are coming
a year ago
- Kristian Cook's struggle with obesity and his participation in a clinical trial combining semaglutide (Ozempic/Wegovy) with an experimental muscle-preserving drug, bimagrumab.
- Concerns about muscle loss with GLP-1 agonists like semaglutide and the development of over 100 anti-obesity drug candidates targeting various pathways.
- The success of semaglutide and tirzepatide (Zepbound/Mounjaro) in the obesity drug market, projected to exceed $100 billion by 2030, despite limitations like side effects and muscle loss.
- Emerging therapies aim to improve weight loss, tolerability, and long-term effects, with drugs like orforglipron, CagriSema, survodutide, and retatrutide expected to hit the market by 2028.
- Tirzepatide's dual action on GLP-1 and GIP hormones leads to superior weight loss compared to semaglutide, inspiring new drug developments targeting multiple pathways.
- Potential risks and uncertainties with new obesity drugs, including effects on bone health and long-term metabolic impacts, leading some clinicians to prefer bariatric surgery.
- Exploration of alternative drug delivery methods, such as once-monthly injectables and oral GLP-1 pills like orforglipron, to improve patient adherence.
- Genetic research uncovering rare variants linked to low body weight and healthier fat distribution, inspiring new drug targets beyond gut hormones.
- Renewed interest in cannabinoid receptor CB1 inhibitors, like monlunabant, aiming to avoid brain-related side effects while maintaining metabolic benefits.
People who stop weight loss drugs return to original weight within year
a year ago
- People regain all lost weight within a year after stopping weight loss drugs.
- Analysis of 11 studies shows patients lost 8kg on average but returned to original weight within 10 months post-treatment.
- Newer drugs like Wegovy and Mounjaro led to greater weight loss (16kg) but patients regained 9.6kg within a year.
- Weight regain is faster after stopping drugs compared to diets, which take at least five years for full regain.
- NHS guidelines limit weight loss injections to two years, raising concerns about long-term effectiveness and cost.
- Experts suggest lifelong treatment or better behavioral support post-drugs to maintain weight loss.
- Psychological counseling and behavior change strategies are recommended to sustain weight loss after stopping injections.
- GLP-1 drugs are not a quick fix; lifestyle changes are essential for long-term weight management.
Waist-to-height ratio predicts heart failure incidence
a year ago
- Risk of heart failure (HF) increases with higher body mass index (BMI), but BMI has limitations as an obesity measure.
- Waist-to-height ratio (WtHR) significantly predicts incident HF over a median follow-up of 13 years in the Malmö Preventive Project.
- WtHR may be a better metric than BMI for identifying HF patients who could benefit from targeted obesity interventions.
- BMI is influenced by factors like sex and ethnicity and does not account for body fat distribution, unlike WtHR.
- Higher WtHR was associated with a significantly increased risk of HF, independent of confounders.
- Individuals with the highest WtHR values had a significantly higher risk of HF compared to those in lower quartiles.
- A waist measurement less than half of height is ideal for reducing cardiometabolic risk.
- WtHR could be a better predictor for HF and other cardiometabolic disorders, warranting further research in larger cohorts.
Newfound Mechanism Rewires Cellular Energy Processing for Drastic Weight Loss
a year ago
- Mice lacking cysteine lost 30% of their body weight in one week due to disrupted metabolic pathways.
- Cysteine depletion lowers coenzyme A (CoA) levels, affecting energy conversion from carbohydrates and fats.
- The study reveals that cysteine deprivation activates interconnected biological pathways leading to rapid fat loss.
- Cysteine is found in nearly all foods, making a cysteine-free diet impractical for humans.
- Fruits, vegetables, and legumes have lower cysteine levels compared to red meat.
- The study highlights the role of cysteine in oxidative phosphorylation and ATP production.
- Cysteine restriction activates both the integrated stress response (ISR) and oxidative stress response (OSR).
- The research was supported by Howard Hughes Medical Institute, Blavatnik Family Foundation, and NIH grants.
- Future research aims to explore targeted cysteine reduction for weight loss without complete deprivation.
Food structure plays key role in which gut hormones are released
10 months ago
- A new study from Imperial College London shows that the physical structure of food influences digestion-related hormones like GLP-1, GIP, and PYY, as well as blood sugar, insulin, and satiety responses.
- Meals with broken cell structures led to rapid increases in blood glucose, insulin, and GIP, while intact cell structures promoted prolonged release of GLP-1 and PYY, enhancing fullness.
- The study involved 10 participants who consumed chickpea meals with different cellular structures (intact vs. broken), revealing significant differences in metabolic responses.
- Findings suggest that food structure manipulation could help combat obesity and type 2 diabetes by optimizing hormone release and satiety.
- Researchers emphasize the potential for designing foods to naturally enhance GLP-1 production, offering a dietary approach to managing appetite and metabolic health.
- The study was published in Nature Metabolism, highlighting the importance of food processing in metabolic responses.
New Duke study finds obesity rises with caloric intake, not couch time
9 months ago
- Duke University study identifies higher caloric intake as the primary driver of obesity worldwide.
- Research challenges the notion that reduced physical activity is the main cause of obesity in industrialized nations.
- Study analyzed data from over 4,200 adults across 34 populations, including hunter-gatherers and industrialized societies.
- Findings suggest that dietary changes, not decreased energy expenditure, are responsible for rising obesity rates.
- Public health strategies should prioritize both diet and physical activity as complementary factors in combating obesity.
- Future research aims to identify specific dietary factors contributing to obesity in developed countries.
New Duke Study Finds Obesity Rises with Caloric Intake, Not Couch Time
9 months ago
- Study from Duke University's Pontzer Lab examines links between economic development, daily energy expenditure, and obesity.
- Findings challenge the idea that declining physical activity due to industrialization is the main cause of obesity.
- Higher caloric intake, not reduced activity, is identified as the primary driver of obesity in wealthier countries.
- Researchers analyzed data from over 4,200 adults across 34 populations, including hunter-gatherers and industrialized societies.
- United Nations Human Development Index (HDI) data was used to assess industrialization levels.
- Marginal decrease in energy expenditure with economic development does not fully explain rising obesity rates.
- Dietary changes are suggested as the main factor behind increasing body fat in developed nations.
- Public health strategies should prioritize both diet and physical activity, viewing them as complementary.
- Future research will focus on identifying specific dietary factors contributing to obesity in developed countries.
You can't outrun a bad diet
9 months ago
- Obesity was almost nonexistent in the 1800s but has become common in industrialized nations.
- A new study found that total calorie burn is similar across different populations, regardless of activity levels.
- The study suggests diet, not lack of physical activity, is the major driver of weight gain and obesity.
- Researchers used isotopes in water to measure daily calorie expenditure accurately.
- Differences in energy expenditure between populations with high and low obesity rates were minimal.
- The body adjusts energy expenditure to maintain a stable total calorie burn.
- Ultra-processed foods are linked to higher obesity rates and body fat percentages.
- Public health messages should focus on diet rather than physical activity to tackle obesity.
- Exercise remains important for mental and physical health, independent of weight management.
Teflon diet, garlic milk and zebra cows triumph at 2025 Ig Nobel prizes
7 months ago
- Researchers propose using Teflon (PTFE) as a zero-calorie filler in food to reduce calorie intake, winning an Ig Nobel prize.
- Ig Nobel awards celebrate humorous yet thought-provoking research, distinct from the prestigious Nobel prizes.
- Other winners include studies on alcohol improving foreign language skills, cows painted as zebras suffering fewer insect bites, and narcissism linked to perceived intelligence.
- A doctor who measured his nail growth for 35 years also received an award.
- Research showed small doses of alcohol boost confidence in foreign language skills but don't drastically improve proficiency.
- Ethanol affects Egyptian fruit bats similarly to humans, impairing their echolocation and increasing collision risks.
- Diet impacts breast milk flavor, with garlic leading to longer suckling times in babies.
- A phase transition in cacio e pepe pasta causes clumping, earning a physics prize.
- Rainbow lizards in Togo showed a strong preference for 'four cheeses' pizzas.
- An Indian team built a UV shoe rack that neutralizes odor but also burns shoes.
- Cows painted with black stripes suffered fewer fly bites, winning a biology prize.
- A late doctor's 35-year study on nail growth earned a posthumous literature prize.
Stop blaming yourself for your expanding waistline
7 months ago
- Dr. Kevin Hall conducted two gold-standard clinical trials on ultraprocessed foods' impact on obesity.
- Ultraprocessed foods led to increased calorie intake by 500-1,000 calories per day in clinical trials.
- Energy-dense and hyperpalatable ultraprocessed foods are major contributors to overeating.
- Hall's book 'Food Intelligence' explores how food both nourishes and harms us, coauthored with Julia Belluz.
- Hall criticizes the food environment for making healthy choices difficult, not lack of willpower.
- Ultraprocessed foods disrupt gut-brain signals, contributing to overeating and potential addiction-like behaviors.
- Current food labels make it hard for consumers to identify energy density and hyperpalatability.
- Hall advises choosing ultraprocessed foods with better nutritional profiles to support a healthier diet.
- Precision nutrition is currently more hype than science, lacking strong evidence for personalized diet benefits.
- Metabolism-boosting supplements are ineffective and sometimes dangerous, as shown in 'The Biggest Loser' study.
Almost 70% of US adults would be deemed obese based on new definition
7 months ago
- Almost 70% of US adults would be classified as obese under a new definition, compared to 43% under the traditional BMI-based criteria.
- The new definition considers factors beyond BMI, such as waist circumference, waist-to-hip ratio, and direct measures of excess body fat.
- Obesity is now split into two categories: clinical obesity (with signs of illness) and pre-clinical obesity (without signs).
- The new criteria identify individuals with normal BMI but high abdominal fat, who may still face health risks like pre-diabetes or fatty liver.
- Men showed a greater increase in obesity prevalence under the new definition compared to women, with the highest relative rise among Asian individuals.
- Experts emphasize the need for more effective strategies to address rising obesity levels, especially in high-income countries.
Weight loss drugs are bringing down the country's obesity rate
6 months ago
- Obesity rate in U.S. adults dropped to 37% from 39.9% three years ago.
- Use of weight loss drugs like semaglutide and tirzepatide more than doubled in the past year and a half.
- GLP-1 agonists, approved in 2021, are considered a breakthrough in obesity treatment.
- Obesity rates declined more among those aged 40-64, correlating with higher GLP-1 medication use.
- Access to GLP-1 drugs is limited, with many insurers stopping coverage, making them expensive for patients.
GLP-1 Drugs Linked to Dramatically Lower Death Rates in Colon Cancer Patients
6 months ago
- GLP-1 receptor agonists like Ozempic and Wegovy linked to significantly lower death rates in colon cancer patients.
- Study of 6,800 patients showed GLP-1 users had less than half the mortality rate within five years compared to non-users.
- Survival benefit was most notable in patients with a BMI over 35, suggesting anti-inflammatory and metabolic improvements.
- Potential mechanisms include reduced inflammation, improved insulin sensitivity, weight loss, and direct anti-cancer effects.
- Authors call for clinical trials to confirm findings and explore GLP-1 drugs' role in improving cancer survival rates.
Obesity drugs quiet 'food noise' in the brain
6 months ago
- Obesity drug tirzepatide (Mounjaro/Zepbound) may suppress brain activity linked to food cravings.
- Study observed reduced 'food noise'—intrusive thoughts about eating—in a person with severe obesity after taking tirzepatide.
- Researchers initially aimed to test deep brain stimulation for compulsive eating but found unexpected effects of tirzepatide.
- Electrodes implanted in the nucleus accumbens recorded surges in low-frequency brain activity during food cravings.
- A participant on tirzepatide showed suppressed food-related brain activity, suggesting the drug's potential neural impact.
- Findings highlight the role of GLP-1 receptors in modulating reward-related brain activity.
Weight loss jabs: What happens when you stop taking them
4 months ago
- Weight loss jabs (GLP-1s) suppress hunger but rebound hunger occurs when stopping.
- Long-term side effects of GLP-1 drugs are still unknown due to their novelty.
- Tanya Hall lost significant weight but struggles with side effects and rebound hunger when stopping Wegovy.
- Ellen Ogley used Mounjaro to break binge-eating habits but faced weight regain post-treatment.
- Doctors emphasize the need for exit strategies and lifestyle support to maintain weight loss after stopping injections.
- Private users often lack structured post-treatment support, increasing relapse risks.
- Obesity is not just a GLP-1 deficiency; societal and environmental factors play major roles.
The myth of willpower – why some people struggle to lose weight more than others
4 months ago
- The myth that obesity is solely a matter of willpower is widely held, including by some medical professionals.
- Genetics play a significant role in obesity, with certain genes affecting hunger, fullness, and metabolism.
- The MC4R gene mutation, carried by about a fifth of the global population, encourages overeating and reduces feelings of fullness.
- Set weight point theory suggests the body has a preferred weight range it tries to maintain, making sustained weight loss difficult.
- Leptin, a hormone produced by fat cells, signals the brain about energy storage, but its effectiveness can be diluted by high insulin levels.
- The obesogenic environment, characterized by abundant high-calorie foods, aggressive marketing, and limited physical activity opportunities, contributes to rising obesity rates.
- Public health measures, such as banning junk food ads before 9pm, aim to tackle obesity but may have limited impact.
- Debate exists over the role of personal responsibility versus environmental factors in obesity, with some arguing for more regulation and others emphasizing individual choice.
- Willpower is influenced by mood, fatigue, and hunger, and flexible approaches to eating are more successful than rigid ones.
- Understanding the biological and environmental factors behind obesity can improve support systems and long-term success in weight management.
People who come off slimming jabs regain weight four times faster than dieters
4 months ago
- People who stop using weight-loss injections like Mounjaro or Wegovy regain weight four times faster than those who stop conventional dieting.
- On average, users regain 0.8 kg per month after stopping injections, returning to pre-treatment weight in about a year and a half.
- Conventional dieters regain weight more slowly, around 0.1 kg per month, though results vary.
- The NHS recommends these injections only for overweight individuals with obesity-related health risks, not for those wanting minor weight loss.
- Doctors should prescribe lifestyle changes alongside injections to help maintain weight loss.
- Many experts suggest these treatments should be lifelong due to the high risk of relapse.
- GLP-1 drugs like Wegovy and Mounjaro mimic a natural hormone that regulates hunger, but stopping them can lead to increased appetite and overeating.
- Around 1.6 million UK adults used these injections in the past year, with 3.3 million more interested in trying them.
- Use is more common among women and people in their 40s and 50s.
- Short-term use of these drugs may provide health benefits, but long-term use is often necessary to maintain weight loss.
- Mounjaro and Wegovy are not automatically prescribed on the NHS; they are reserved for those with significant clinical need.
- Pharmaceutical companies emphasize that obesity is a chronic condition requiring ongoing treatment, similar to diabetes or hypertension.
Why We just can't stop eating
3 months ago
- Obesity is not just about greed or lack of willpower; it's influenced by complex biological and environmental factors.
- Gut hormones like GLP-1 play a crucial role in signaling fullness, and their levels can change dramatically after gastric bypass surgery.
- Research shows that a mother's diet during pregnancy can 'program' her child's hypothalamus, leading to a higher risk of obesity in offspring.
- Genetic factors, such as faults in the POMC gene, can predispose individuals to severe obesity, highlighting the role of DNA in weight regulation.
- Environmental cues, like portion sizes and plate dimensions, significantly influence how much we eat, often without our conscious awareness.
- Fast food accessibility, especially in deprived areas, correlates with higher obesity rates, emphasizing the need for policy changes to enable healthier choices.
- The 'fundamental attribution error' leads to blaming individuals for obesity, ignoring the complex interplay of genetics, environment, and biology.
- New research facilities aim to study obesity by controlling environmental factors and examining the behavior of both obese and naturally thin individuals.
- Interventions like reducing wine glass size can decrease alcohol consumption, showing how subtle environmental changes can impact behavior.
- Local policies, supported by tools like the Food Environment Assessment Tool (Feat), can help restrict fast food outlets and promote healthier communities.
Big Food Is Killing Our Children
3 months ago
- Americans are experiencing declining life expectancy and rising chronic diseases despite high healthcare spending.
- The Make America Healthy Again (MAHA) movement, led by Robert F. Kennedy Jr., reflects growing mistrust in the medical establishment.
- Mark Hyman's new book, 'Food Fix Uncensored,' critiques government and corporate malpractice in the health system.
- Childhood obesity rates have nearly quadrupled since the 1970s, with 36% of children overweight or obese.
- One in four teenagers has type 2 diabetes or prediabetes, previously known as 'adult-onset diabetes.'
- The Big Food lobby and political leaders prioritizing profit over health are blamed for the crisis.

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#obesity

Why Do Most People Quit Ozempic After Two Years?

New obesity drugs are coming

People who stop weight loss drugs return to original weight within year

Waist-to-height ratio predicts heart failure incidence

Newfound Mechanism Rewires Cellular Energy Processing for Drastic Weight Loss

Food structure plays key role in which gut hormones are released

New Duke study finds obesity rises with caloric intake, not couch time

New Duke Study Finds Obesity Rises with Caloric Intake, Not Couch Time

You can't outrun a bad diet

Teflon diet, garlic milk and zebra cows triumph at 2025 Ig Nobel prizes

Stop blaming yourself for your expanding waistline

Almost 70% of US adults would be deemed obese based on new definition

Weight loss drugs are bringing down the country's obesity rate

GLP-1 Drugs Linked to Dramatically Lower Death Rates in Colon Cancer Patients

Obesity drugs quiet 'food noise' in the brain

Weight loss jabs: What happens when you stop taking them

The myth of willpower – why some people struggle to lose weight more than others

People who come off slimming jabs regain weight four times faster than dieters

Why We just can't stop eating

Big Food Is Killing Our Children