- There is a cultural bias favoring psychedelic therapies using natural compounds over synthetic ones, despite both acting similarly on brain receptors.
- Discussing 'negative valence' phenethylamines helps understand what doesn't work, aiding in the design of better compounds.
- Phenethylamines have a less ideal safety profile due to vasoconstriction and serotonin syndrome risks, with deaths often from mishandling.
- 2C-P has high potency and long activity (up to 20 hours) with variable subjective effects and physical discomfort.
- 2C-G has subdued effects as an 'insight enhancer' but an extremely long duration (18-30 hours) limits its use.
- Bromo-DragonFLY is dangerous with extreme vasoconstriction, seizures, and effects lasting up to 3 days.
- 25B-NBOMe has high potency (250-500 µg) and risks like thrombosis, with a narrow safety margin.
- 3C-BZ shows dose-dependent effects from amphetamine-like at low doses to tryptamine-like at high doses.
- 2C-G5 has a unique structure and duration up to 48 hours, with potential for optical isomer studies.
- Cataloging unfavorable phenethylamines aims to improve understanding and future drug design.