RNA-binding proteins Zfp36l1 and Zfp36l2 protect against premature thymic involution - PubMed
5 hours ago
- #Central tolerance
- #RNA-binding proteins
- #Thymic involution
- RNA-binding proteins Zfp36l1 and Zfp36l2 protect against premature thymic involution.
- Conditional deletion of Zfp36l1 and Zfp36l2 in thymic epithelial cells (TECs) leads to reduced TEC numbers during embryonic and early neonatal stages.
- Postnatally, these mice show excessive medullary TEC (mTEC) expansion, elevated proinflammatory cytokines, FOXN1 downregulation, and premature thymic involution.
- Zfp36 Tristetraprolin (TTP) family proteins regulate cytokine levels in the thymic microenvironment, preventing premature involution.
- The study suggests a link between central tolerance induction and age-associated thymic involution.