Omics insights into MYBL2-promoted cancer stem-like cells driving ferroptosis resistance in hepatocellular carcinoma - PubMed
3 hours ago
- #Cancer Stem Cells
- #Ferroptosis Resistance
- #Hepatocellular Carcinoma
- Cancer stem cells (CSCs) play a critical role in hepatocellular carcinoma (HCC) initiation and progression.
- Single-nucleus and single-cell RNA sequencing identified cancer stem-like cells (CSLCs) as key drivers of HCC with stemness properties.
- CSLCs exhibit resistance to ferroptosis by suppressing lipid peroxidation, aiding their survival in the tumor microenvironment.
- MYBL2 is specifically activated in CSLCs; its knockdown reduces cancer stemness and ferroptosis resistance.
- A six-gene CSLC signature (CSLC.Sig) model shows strong prognostic prediction for HCC.
- CSLCs interact with activated hepatic stellate cells, forming a pro-tumorigenic niche.
- The study highlights MYBL2-driven CSLCs as potential therapeutic targets in HCC.