Optimizing VCTE and ELF Thresholds for Treatment-Eligible F2-F3 Fibrosis in Japanese Patients With MASLD - PubMed
7 hours ago
- #Liver Fibrosis
- #Non-invasive Testing
- #MASLD
- Study aimed to assess if Western guideline-recommended cutoffs for VCTE and ELF tests accurately identify treatment-eligible F2-F3 fibrosis in Japanese MASLD patients.
- Analyzed 838 patients for VCTE and 657 for ELF, excluding those with low FIB-4 scores, using ROC analyses to determine optimal cutoffs.
- VCTE cutoff of 8 kPa for F2-4 showed 83.7% sensitivity and 61.2% specificity, while 15 kPa for F4 showed 88.1% sensitivity and 76.8% specificity.
- ELF cutoff of 9.2 for F2-4 showed 94.7% sensitivity and 23.1% specificity, while 10.5 for F4 showed 80.0% sensitivity and 58.4% specificity.
- ROC-derived cutoffs (VCTE: 9.5/15 kPa; ELF: 10.3/10.8) improved specificity for F2-4 and F4 predictions.
- Test-positive patients showed higher likelihood of F2-3 fibrosis (69.2% for VCTE 8-15 kPa; 49.8% for ELF 9.2-10.5).
- Western cutoffs effectively exclude cirrhosis but higher values (VCTE >15 kPa, ELF >10.5) warrant further clinical assessment for treatment eligibility.