Unlocking the potential of T cell engagers in solid tumors - PubMed
3 hours ago
- #solid tumors
- #immunotherapy
- #T cell engagers
- T cell engagers (TCEs) are a targeted immunotherapy reshaping cancer treatment.
- Multiple TCEs are approved for hematologic malignancies, but development in solid tumors faces challenges like target heterogeneity, immunosuppressive microenvironment, and on-target toxicity.
- Key principles for next-generation TCEs include target selection, protein engineering, and thoughtful clinical design.