Peripheral Inflammatory Biomarkers in Parkinson's Disease: Clinical Correlations and Stratification - PubMed
5 days ago
- #Biomarkers
- #Parkinson’s disease
- #Neuroinflammation
- Peripheral inflammatory biomarkers in Parkinson's disease (PD) show associations with clinical features and progression.
- Key biomarkers include neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI).
- NLR and SII were significantly elevated in PD, with NLR showing the strongest association with both non-motor and motor symptoms.
- Cluster analysis identified two distinct inflammatory clusters: a high-inflammation cluster associated with worse cognitive function, olfactory impairment, autonomic dysfunction, and accelerated motor and cognitive decline.
- The high-inflammation cluster also showed elevated CSF neurodegeneration markers, including pTau, tTau, NfL, and GFAP.
- Peripheral inflammatory biomarkers may serve as markers for disease features and progression, suggesting a basis for inflammatory-based subgrouping in PD.