Potential role of titanium particles in peri-implantitis: Evidence from an integrated clinical, in vivo, and in vitro study - PubMed
4 hours ago
- #Autophagy
- #Peri-implantitis
- #Titanium particles
- Peri-implantitis is a significant challenge in oral implantology with unclear etiology.
- Titanium particles play a critical role in peri-implantitis progression.
- Clinical samples and cellular assays were used to study titanium particle-induced inflammation.
- Transcriptomic analysis showed upregulation of inflammatory and osteoclast-related pathways.
- Titanium particles exacerbate inflammation via hyperactivated autophagy in macrophages.
- Findings highlight the need to target biomaterial-derived particles in implant design.