Potential of HSP90AA1 as Diagnostic, Prognostic, and Immunological Biomarkers in Human Cancer Demonstrated through Pan-Cancer Investigation: A Bioinformatics Analysis - PubMed
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- #Biomarker
- #HSP90AA1
- #Pan-cancer
- HSP90AA1 gene's role in various cancers is explored through pan-cancer investigation.
- HSP90AA1 mRNA and protein expression levels analyzed across human organs and 33 cancer types.
- Elevated HSP90AA1 mRNA expression found in cancers compared to normal tissues.
- HSP90AA1 identified as a potential diagnostic and prognostic biomarker in multiple cancers.
- High HSP90AA1 expression linked to poorer prognosis and immune system-related pathways.
- HSP90AA1 mutations most common at location X585.
- Association found between HSP90AA1 expression and immune cell infiltration in cancers.
- Future research aims to validate HSP90AA1's role through cellular and functional assays.
- Development of targeted drugs for HSP90AA1 locus suggested as a future challenge.