Human hippocampal neurogenesis in adulthood, ageing and Alzheimer's disease - PubMed
3 hours ago
- #Alzheimer's disease
- #cognitive ageing
- #neurogenesis
- Human hippocampal neurogenesis in adulthood, ageing, and Alzheimer's disease (AD) is a debated topic with unclear cognitive relevance.
- Recent studies confirm the presence of proliferating progenitors and immature neurons, with reductions observed in AD.
- Multiomic single-cell sequencing of 355,997 nuclei identified neural stem cells, neuroblasts, and immature granule neurons.
- Dysregulated neurogenesis is linked to changes in chromatin accessibility, especially in preclinical and AD cases.
- SuperAgers exhibit a unique neurogenesis profile, suggesting a 'resilience signature' against cognitive decline.
- Astrocytes and CA1 neurons play a key role in cognitive function during ageing.
- The study provides a multiomic molecular signature distinguishing cognitive resilience and deterioration in ageing.