Core targets of bisphenol A in cervical cancer revealed by network toxicology and molecular docking - PubMed
5 days ago
- #Bisphenol A
- #Molecular Docking
- #Cervical Cancer
- Bisphenol A (BPA) is studied for its role in cervical cancer through network toxicology and molecular docking.
- BPA exhibits endocrine toxicity and causes tissue damage via matrix metalloproteinases.
- 3 core targets of BPA were identified across databases.
- In cervical cancer, 803 genes were up-regulated and 1092 were down-regulated.
- Weighted Gene Co-expression Network Analysis (WGCNA) identified the turquoise module with 1110 DEGs overlapping.
- 19 common targets between BPA and cervical cancer were found, enriched in gene expression regulation and cancer pathways.
- Estrogen Receptor 1 (ESR1) and Poly [ADP-ribose] Polymerase 1 (PARP1) were confirmed as core targets via PPI analysis.
- ESR1 was down-regulated in cervical cancer, while PARP1 was up-regulated.
- Molecular docking showed stable binding of BPA to ESR1 and PARP1.
- BPA may promote cervical cancer by interacting with ESR1 and PARP1, affecting key cancer-related pathways.
- These targets could serve as biomarkers and therapeutic intervention points.