Efficient generation of human dorsal spinal GABAergic progenitors for the treatment of spinal cord injury - PubMed
4 days ago
- #neuropathic pain
- #spinal cord injury
- #GABAergic progenitors
- Traumatic spinal cord injury (SCI) leads to necrotic cell death, causing neuronal and glial loss.
- Disruption of GABAergic inhibitory tone in the dorsal horn results in neuropathic pain and excitotoxicity.
- GABA has neuroprotective properties, aiding in secondary injury mitigation and neurite outgrowth.
- Human neural stem cell therapies for SCI are limited by hostile injury microenvironments and default differentiation pathways.
- Key transcription factors efficiently convert human pluripotent stem cells into dorsal spinal GABAergic progenitors.
- Induced GABAergic progenitors show resilience, generate mature neurons, and integrate functionally post-SCI.
- Progenitors reduce apoptosis, inhibit glial scar formation, and stimulate endogenous neurogenesis.
- Grafts improve neuropathic pain within 6 weeks and enhance locomotor activities, showing clinical potential.