Targeting the tumor microenvironment: reprogramming macrophages as a novel therapeutic strategy in FUOM-deficient glioblastoma - PubMed
3 hours ago
- #macrophage reprogramming
- #tumor microenvironment
- #glioblastoma
- FUOM is highly expressed in glioma tissues and linked to aggressive tumor progression and poor patient prognosis.
- Downregulation of FUOM leads to macrophage infiltration into the glioma tumor microenvironment and induces CXCL13 release, promoting an M2-like macrophage phenotype.
- Conditioned media from FUOM knockdown glioma cells triggers chemotactic migration of M2-like macrophages.
- Blocking FUOM expression in glioma models enhances M2-like macrophage polarization and increases migration both in vitro and in vivo.
- FUOM promotes glioma progression by mediating CXCL13 secretion to induce M2-like macrophage polarization, suggesting a novel therapeutic target in the tumor microenvironment.