The skin microbiota drives cutaneous immune checkpoint inhibitor toxicity in genetically susceptible mice - PubMed
7 hours ago
- #Autoimmunity
- #Microbiome
- #Cancer Therapy
- The study found that the skin microbiota can drive systemic toxicity from immune checkpoint inhibitors (ICIs) in genetically susceptible mice.
- Using Act1-/- mice, which are prone to autoimmunity, researchers observed that ICI treatment caused adverse events in specific pathogen-free (SPF) mice but not in germ-free (GF) mice.
- Topical antibiotics reduced ICI-induced toxicity in SPF Act1-/- mice, and transferring skin microbiota from SPF to GF mice made them sensitive to toxicity, while gut microbiota did not.
- This model suggests that targeting skin microbes could help mitigate ICI side effects without compromising anti-tumor efficacy in cancer patients.