Piezoelectric Ceramic Nanofiber Aerogels Direct Neutrophil Fate for Diabetic Tissue Regeneration - PubMed
5 days ago
- #piezoelectric materials
- #neutrophil fate
- #diabetic tissue regeneration
- Piezoelectric ceramic nanofiber aerogels (KAP) developed to direct neutrophil fate for diabetic tissue regeneration.
- KAP switches neutrophil death from pyroptosis to apoptosis via peretinoin, suppressing caspase-3-mediated cleavage of gasdermin E (GSDME).
- Ultrasound activation of KAP enhances macrophage phagocytic capacity through calcium influx and lysosomal acidification.
- Dual mechano-chemical approach promotes efferocytosis and reprograms macrophages toward a pro-regenerative phenotype.
- KAP accelerates healing of both soft and hard tissues in diabetic rodent models.
- Potential therapeutic approach for diabetic tissue regeneration by breaking the cycle of chronic inflammation.