Comparison of the effect of neostigmine and sugammadex on postoperative delirium in surgical patients: A systematic review and meta-analysis - PubMed
4 days ago
- #neostigmine
- #sugammadex
- #postoperative delirium
- Sugammadex reduces postoperative delirium (POD) incidence compared to neostigmine in randomized controlled trials (RCTs).
- The benefit of sugammadex is most significant within the first 24 hours after surgery.
- Subgroup analysis in RCTs showed no significant difference in POD incidence based on the type of anticholinergic coadministered with neostigmine.
- Non-randomized controlled trials (NRCTs) did not show a significant difference in POD incidence between sugammadex and neostigmine.
- Mini-Mental State Examination (MMSE) scores were similar between groups preoperatively and postoperatively.
- Further well-designed RCTs with standardized delirium assessments are recommended.