Messenger RNA delivery to islet β cells using conjugated lipid nanoparticles - PubMed
4 hours ago
- #Lipid Nanoparticles
- #Type 1 Diabetes
- #mRNA delivery
- Development of a lipid nanoparticle (LNP) platform for β cell-enriched mRNA delivery, enhanced by conjugation to glucagon-like peptide-1 (eGLP-1).
- Demonstration of efficient mRNA delivery to both mouse and human β cells in vitro and in vivo, with pancreatic enrichment observed in mice.
- Use of LNPs to deliver PD-L1 mRNA in prediabetic NOD mice, resulting in PD-L1 expression in β cells, reduced insulitis, and delayed onset of autoimmune diabetes.
- Confirmation of mRNA delivery to human β cells in a xenogeneic islet transplantation model, highlighting translational relevance.
- Provisional patent filed by authors on the use of LNPs for targeting β cells.