Early Epidemiologic and Immune Predictors of Atopic Dermatitis: Reduced Cord Blood Regulatory B10 Cells in the Munich Atopy Prediction Study (MAPS) - PubMed
4 hours ago
- #immune regulation
- #atopic dermatitis
- #Breg cells
- Maternal AD and affected siblings increase the risk of atopic dermatitis (AD) in infants.
- Cold-remedy intake shows a protective association against AD development.
- Infants later diagnosed with AD have reduced CD4+ T cells and increased B-cell counts.
- First identification of significant reduction in regulatory B (Breg)-cell frequencies in AD infants.
- Maternal allergen-specific immunotherapy may benefit Breg cell development and frequency.
- Early immune alterations, particularly reduced cord blood Breg cells, may contribute to AD pathogenesis.
- Incorporating Breg-cell measurements into neonatal immune panels could improve early risk stratification.