ASB9 promotes ubiquitin-mediated degradation of TNP2 to facilitate histone-to-protamine transition in humans and mice - PubMed
4 hours ago
- #Ubiquitination
- #Spermiogenesis
- #Male Infertility
- ASB9 deficiency leads to TNP2 retention, disrupting histone-to-protamine transition and causing male infertility.
- ASB9 forms a testis-specific CRL complex (TNP2-ASB9-ELOB/C-CUL5-RBX1) that mediates ubiquitin-dependent degradation of TNP2.
- Disruption of TNP2 degradation results in sperm head malformation and impaired fertilization and early embryonic development.