Non-invasive high-frequency oscillation ventilation versus nasal CPAP as primary respiratory support in preterm neonates ≥ 30 weeks with RDS: a non-inferiority randomized controlled trial - PubMed
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- The study compares NHFOV versus CPAP as primary respiratory support for preterm neonates ≥ 30 weeks with RDS in a non-inferiority RCT.
- NHFOV was found non-inferior to CPAP, with similar treatment failure (4.2% in both groups) and IMV requirement outcomes.
- NHFOV had a significantly shorter duration of primary respiratory support (median difference 7 hours less) and more ventilator-free days.