Impact of Alkaline Phosphatase Normalization on Complication-Free Survival in Primary Biliary Cholangitis - PubMed
4 hours ago
- #Ursodeoxycholic Acid
- #Alkaline Phosphatase
- #Primary Biliary Cholangitis
- Normalization of alkaline phosphatase (ALP) and total bilirubin (TB) ≤0.6xULN in primary biliary cholangitis (PBC) patients on UDCA therapy significantly improves complication-free survival.
- Patients achieving ALP normalization alone had 1.34 years longer event-free survival, while those with TB ≤0.6xULN had 3.7 years longer, and those meeting both criteria had 4.51 years longer.
- High-risk PBC patients (LSM ≥10 kPa or evidence of cirrhosis/portal hypertension) derived the greatest survival benefit from ALP/TB normalization.
- The study suggests biochemical thresholds (ALP normalization and TB ≤0.6xULN) should be considered as therapeutic goals in PBC management.