Heterogeneity of Treatment Effects of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss in Adults: A Systematic Review and Meta-Analysis - PubMed
3 hours ago
- #weight loss
- #GLP-1 receptor agonists
- #meta-analysis
- GLP-1 receptor agonists (GLP-1 RAs) are used to treat cardiovascular disease, diabetes, and obesity, but their efficacy across different patient groups was unclear.
- A systematic review and meta-analysis of 64 RCTs found that GLP-1 RAs led to greater weight loss in women (10.9%) compared to men (6.8%).
- No significant differences in treatment effects were observed based on age, race, ethnicity, baseline BMI, or baseline HbA1c levels.
- The study highlights the importance of considering sex differences when prescribing GLP-1 RAs for weight loss.