Risk of Breast Cancer After Ovarian Cancer in Women With a Pathogenic/Likely Pathogenic Variant in BRCA1 or BRCA2 - PubMed
3 hours ago
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- #Ovarian Cancer
- BRCA carriers with ovarian cancer have a relatively low risk of developing breast cancer.
- The study included 960 women with BRCA1 or BRCA2 variants and ovarian cancer, with 4.3% developing breast cancer over a mean follow-up of 4.9 years.
- Cumulative breast cancer risks after ovarian cancer were 4.4% at 5 years, 8.9% at 10 years, and 11.5% at 15 years.
- BRCA carriers without ovarian cancer had significantly higher cumulative breast cancer risks: 20.9% at 5 years, 38.6% at 10 years, and 47.2% at 15 years.
- The hazard ratio for breast cancer after ovarian cancer was 0.18 compared to those without ovarian cancer.
- Risk-reducing mastectomy is not routinely recommended for BRCA carriers post-ovarian cancer but may be considered for long-term survivors.
- Magnetic resonance imaging surveillance and/or mammography are viable alternatives to mastectomy.