Baloxavir alleviates severe disease and viremia in ferrets infected with avian- or bovine-origin influenza A(H5N1) virus - PubMed
3 days ago
- #Baloxavir
- #Ferrets
- #Influenza A(H5N1)
- Baloxavir improves survival and clinical outcomes in ferrets infected with avian- or bovine-origin A(H5N1) virus.
- Multidose baloxavir therapy showed the best outcomes, reducing virus shedding, lung pathology, and viremia.
- Single-dose prophylaxis led to low-frequency PA-E23K substitution, while treatment regimens induced PA-I38T substitution, reducing baloxavir susceptibility.
- PA-E23K and PA-I38T substitutions decreased baloxavir-PA protein interactions, reducing drug effectiveness.
- Multidose baloxavir regimens may be most effective against highly pathogenic avian influenza A(H5N1), controlling severe disease and neurological involvement.