Metabolomic biomarkers enhance 10-year mortality risk calibration and clinical utility in older heart failure patients: A UK Biobank study - PubMed
4 hours ago
- #mortality prediction
- #metabolomics
- #heart failure
- Metabolomic biomarkers improve 10-year mortality risk prediction in older heart failure patients.
- Model combining clinical features and metabolites (e.g., citrate, omega-3 fatty acids) showed better accuracy and calibration than clinical-only model.
- The clinical-plus-metabolites model had higher area under the curve (0.691 vs. 0.662) and better clinical net benefit.
- Study analyzed UK Biobank data from 1,104 heart failure patients aged 60+, linking 19 metabolites to mortality.
- Findings support metabolomic integration for personalized care and highlight metabolic dysfunction and inflammation roles.