Proteomic analyses of human islets reveal potential markers of β-cell dysfunction during prediabetes - PubMed
2 hours ago
- #Proteomics
- #Beta-cell dysfunction
- #Diabetes
- Proteomic analyses of human islets identify markers of β-cell dysfunction during prediabetes.
- Subjects with impaired glucose tolerance (IGT) show reductions in proteins regulating glycolysis, lipid metabolism, glucose transport, and insulin secretion.
- Lower beta-cell glucose sensitivity (βGS) correlates with reduced insulin maturation and anti-apoptotic proteins, and increased SEL1L.
- Early defects in glucose metabolism and insulin secretion characterize IGT, while reduced βGS may trigger compensatory mechanisms.
- Proteomic changes in prediabetic islets offer potential early predictive markers and intervention targets to preserve beta-cell function.