A trans-omics gene-smoking interaction study of lung cancer based on consortium data - PubMed
4 hours ago
- #lung-cancer
- #trans-omics
- #gene-smoking-interaction
- Study investigates gene-smoking interactions in lung cancer susceptibility using trans-omics approach.
- Integrated consortium-scale genotype data from multiple sources including ILCCO-OncoArray, TRICL, PLCO, and UK Biobank.
- Identified eight biomarkers with significant interactions with smoking, including CpG sites and gene RP11-326C3.14.
- Developed a Molecular Modifying Score (MMS) to stratify high-risk smokers.
- Functional analysis implicated the NELFE gene in smoking-related carcinogenesis pathways.
- Launched an online platform, LungCancer-xWAS-GxE, for further research and data access.