Oral microbiome perturbations link periodontal health to cognitive ageing in a large community cohort - PubMed
3 hours ago
- #Periodontal health
- #Cognitive aging
- #Oral microbiome
- Study examines links between oral microbiome, periodontal health, and cognitive aging in a large community cohort.
- Involves 1,157 participants from the Taizhou Imaging Study, assessing periodontal health, salivary microbiome, and cognitive performance.
- Five periodontal indices inversely associated with cognitive performance.
- Identified 10 microbial genera, 21 functional pathways, and two co-abundance modules linked to cognitive function.
- Mediation analysis suggests 11 features may mediate the relationship between periodontal health and cognition.
- Highlights potential of periodontal health and oral microbiome as targets for preventing cognitive decline.
- Funded by multiple Chinese national and municipal research programs.