Matrix stiffness-induced YEATS2 drives HCC progression via epigenetic activation of the TGFBR2-TAZ-AKT pathway - PubMed
8 hours ago
- #YEATS2
- #epigenetics
- #HCC
- YEATS2 is overexpressed in multiple human cancers and linked to poor clinical outcomes.
- YEATS2 expression is significantly elevated in HCC tissues and associated with worse survival rates.
- YEATS2 promotes HCC cell proliferation, migration, and invasion via the TAZ/AKT signaling pathway.
- YEATS2 upregulates TGFBR2, leading to activation of aerobic glycolysis in HCC cells.
- YEATS2 interacts with KAT2A, increasing H3K9ac and H3K14ac levels at the TGFBR2 promoter, enhancing its transcription.
- Matrix stiffness induces YEATS2 expression by increasing HIF-1α binding to the YEATS2 promoter.
- The study identifies a novel YEATS2-TGFBR2-TAZ-AKT signaling axis in HCC progression, suggesting YEATS2 as a therapeutic target.