Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease - PubMed
4 hours ago
- #vitamin-B3
- #NAXD
- #nutrigenomics
- A nutritional genomics framework was developed to identify monogenic diseases responsive to micronutrient modulation.
- Genome-wide CRISPR screens under varying vitamin B2 and B3 levels identified NAXD as a top hit, linked to severe neurodevelopmental disease.
- NAXD knockout mice showed NADHX accumulation, NAD+ depletion, and impaired serine biosynthesis, with brain endothelial cells being particularly vulnerable.
- Low-vitamin B3 diets worsened pathology, while vitamin B3 supplementation extended lifespan by over 40-fold in mice.
- The study highlights the therapeutic potential of precision vitamin interventions for metabolic disorders.