Development and validation of the Risk of Exacerbation in Severe Asthma (RESA) model - PubMed
7 hours ago
- #clinical utility
- #severe asthma
- #risk prediction
- Development and validation of the Risk of Exacerbation in Severe Asthma (RESA) model for predicting severe exacerbations in severe asthma patients.
- Model based on data from 9,911 patients across 30 countries, using 11 routine predictors like age, past exacerbations, and biomarkers.
- Showed excellent calibration and discrimination in validation, with pooled AUC of 0.63 for ≥1 and 0.68 for ≥2 exacerbations.
- Demonstrated potential clinical utility through decision curve analysis, guiding personalized treatment decisions.