Ubiquitin-mediated stabilization of KDM5B drives chemoresistance via repression of dual-specificity phosphatase 4 in ovarian cancer - PubMed
a day ago
- #chemoresistance
- #ovarian cancer
- #epigenetics
- KDM5B overexpression correlates with cisplatin resistance and ovarian cancer (OVC) progression.
- KDM5B removes H3K4me3 from the DUSP4 promoter, activating the MAPK pathway to promote cisplatin resistance.
- KDM5B protein stability is regulated by the ubiquitin-proteasome system (UPS), involving USP7, FBXW7, and HIPK1.
- Depletion of KDM5B and USP7 resensitizes OVC to cisplatin, while DUSP4 silencing induces resistance.
- Targeting the KDM5B-DUSP4 axis offers a novel mechanism to overcome cisplatin resistance in OVC.