Clostridioides difficile-Derived Extracellular Vesicles Induce Proinflammatory Responses in Macrophages - PubMed
3 hours ago
- #Clostridioides difficile
- #Inflammation
- #Extracellular Vesicles
- CD630-derived extracellular vesicles (EVs) stimulate proinflammatory cytokine production (IL-6, MCP-1, IL-1α, TNF-α) in mouse macrophages.
- Proteomic analysis identifies 1064 proteins in CD630-EVs, including immune-related proteins FliC, TrxA, TrxA2, and HtpG, with FliC showing highest expression.
- Inhibition of flagellin receptor (TH1020) suppresses cytokine production; docking analysis shows TH1020 disrupts TLR5-FliC interaction, attenuating inflammation.
- FliC is a key mediator, likely activating innate immunity via TLR5, potentially influencing adaptive immune responses and contributing to intestinal mucosal injury in CDI.
- Study highlights CD630-EVs' immune-modulatory role in macrophages during C. difficile infection and suggests FliC as a potential therapeutic target to mitigate inflammation.