NQO1-Mediated Oxidative Stress Resistance and Tumor Microenvironment Remodeling in Glioblastoma - PubMed
4 hours ago
- #oxidative stress
- #glioblastoma
- #NQO1
- NQO1 is identified as a key regulator in antioxidant stress response in glioblastoma (GBM).
- NQO1 helps maintain glioblastoma stem cells (GSCs) and the immunosuppressive tumor microenvironment (TME).
- Proteomics, epigenetic profiling, and single-cell RNA sequencing show high NQO1 enrichment in GBM.
- NQO1 regulates ROS levels, stabilizes nuclear Lamin B1, and inhibits cGAS-type I interferon signaling.
- NRF2 transcriptionally regulates NQO1, suppressing type I interferon signaling.
- Targeting NQO1 and its pathways (e.g., β-Lapachone, anti-PD-1 therapy) offers new clinical intervention avenues for GBM.