Periodontitis Induces B Cell-Macrophage Crosstalk to Exacerbate Glucose Dysregulation in Obesity - PubMed
5 hours ago
- #B cell-macrophage crosstalk
- #glucose dysregulation
- #periodontitis
- Periodontitis (PD) worsens hyperglycemia and hepatic gluconeogenesis in obese mice.
- PD increases systemic B cell abundance and promotes hepatic B2 cell mobilization.
- PD activates the NLRP3 inflammasome and expands Kupffer cells and adipose tissue macrophages.
- Depleting B cells alleviates PD-induced glucose dysregulation.
- Adoptive transfer of B cells from PD mice exacerbates glucose dysregulation in Rag1-/- mice.
- IL-18 receptor upregulation in PD-exposed B cells drives B cell proliferation.
- Hepatic macrophages from PD mice secrete elevated IL-18, further expanding B cells.
- Neutralizing IL-18 or depleting macrophages mitigates PD-associated metabolic and B cell abnormalities.
- Targeting the NLRP3/IL-18 axis may prevent glucose dysregulation and immune cell interactions caused by PD.