Frailty and frailty progression in relation to the risk of benign prostatic hyperplasia/lower urinary tract symptoms among Chinese middle-aged and older men: a prospective cohort study - PubMed
5 days ago
- #aging
- #BPH/LUTS
- #frailty
- Study investigates the relationship between frailty index (FI) trajectories and the risk of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS) in middle-aged and older Chinese men.
- Four distinct FI trajectories were identified, with Moderately Increasing and High-Increasing trajectories showing significantly higher BPH/LUTS risk compared to Persistently Low trajectory.
- Baseline prefrail and frail statuses were associated with elevated BPH/LUTS risk (ORs: 1.47 and 1.67, respectively).
- Dynamic frailty trajectories demonstrated improved risk reclassification over baseline assessments alone (continuous NRI: 0.284; IDI: 0.011).
- Long-term FI trajectories, especially progressively worsening patterns, are more strongly associated with BPH/LUTS risk than single time-point assessments.
- Highlights the importance of monitoring frailty progression for improved risk stratification and targeted prevention of BPH/LUTS.