Intratumoral microbiota and host genotype cooperatively shape neutrophil cytotoxic functions in colorectal cancer - PubMed
a day ago
- #microbiota
- #neutrophils
- #colorectal cancer
- Tumor-associated neutrophils (TANs) in colorectal cancer (CRC) have their recruitment and functions influenced by intratumoral microbiota.
- Fusobacterium nucleatum enhances neutrophil migration and triggers the release of cytotoxic proteins with tumoricidal activity, unlike Bacteroides fragilis.
- The interaction between Fusobacterium nucleatum and Siglec-14 on neutrophils is crucial for eliciting cytotoxic effects, which are impaired by Siglec-14 blockade or polymorphisms.
- High Fusobacterium nucleatum loads and TAN densities in human CRCs correlate with improved prognosis, while lack of Siglec-14 expression is linked to reduced survival.
- The study highlights microbiota composition and host genetic background as key factors in determining neutrophil functional profiles in CRC.