Pharmacological inhibition of the interleukin-1 receptor-associated kinase prevents angiotensin II-induced cardiac remodelling in mice - PubMed
5 hours ago
- #inflammation
- #cardiac fibrosis
- #IRAK
- Pharmacological inhibition of IRAK-1/4 prevents angiotensin II-induced cardiac remodeling in mice.
- AngII infusion leads to cardiac hypertrophy, inflammation, and fibrosis, which are mitigated by IRAK-1/4 inhibitor.
- IRAK-1/4 inhibitor improves ejection fraction, fractional shortening, and reduces systolic blood pressure and heart weight.
- Reduction in immune cell infiltration and attenuation of fetal gene expression observed with IRAK-1/4 inhibition.
- Mechanistically, IRAK-1/4 inhibitor blocks TLR4-NF-κB and TGFβ-SMAD pathways, suggesting therapeutic potential for heart failure.