Dual phagocytosis-checkpoint blockade revitalizes immune surveillance in mouse models of glioblastoma - PubMed
3 days ago
- #immunotherapy
- #glioblastoma
- #phagocytosis
- Macrophage-mediated phagocytosis of tumor cells can stimulate strong antitumor immunity.
- Glioblastoma (GBM) cells express high levels of the phagocytosis checkpoint CD24.
- Dual blockade of CD24 and CD47 enhances macrophage phagocytic activity.
- This dual blockade improves tumor antigen cross-presentation and activates the cGAS-STING pathway.
- Activation of innate immunity increases T cell infiltration into tumors and enhances response to anti-PD1 therapy.
- Dual-phagocytosis checkpoint blockade shows promise in improving survival in murine GBM models.