Atorvastatin-Associated Liver Injury: Outcome After Statin Rechallenge - PubMed
5 days ago
- #drug-induced liver injury
- #statin rechallenge
- #pharmacovigilance
- Atorvastatin-associated liver injury is frequent but usually not severe.
- The study aimed to assess the safety of statin rechallenge after atorvastatin-induced liver injury.
- 26 cases of atorvastatin liver injury with statin reintroduction were analyzed.
- Median time to onset of the first liver injury episode was 27 days.
- Rechallenge with atorvastatin led to recurrence in 12 of 16 patients.
- Rechallenge with alternative statins (rosuvastatin, pravastatin, simvastatin) showed lower recurrence rates.
- Hydrophilic statins like rosuvastatin or pravastatin were better tolerated with minimal recurrence.
- Study limitations include retrospective design and potential underreporting.