Epigallocatechin-3-Gallate Suppresses Glioma by Targeting Integrin αvβ3/FAK/ERK Signaling Axis and Matrix Metalloproteinases - PubMed
4 hours ago
- #integrin signaling
- #glioma
- #EGCG
- EGCG, a compound in green tea, shows anti-cancer properties in various tumors, including glioma.
- Study focuses on EGCG's effects on glioma cell lines (U87, U251, LN229), showing inhibition of proliferation, migration, and invasion, and induction of apoptosis.
- Mechanistically, EGCG downregulates the integrin αvβ3/FAK/ERK signaling pathway and suppresses MMP-2/MMP-9 expressions.
- In vivo, EGCG monotherapy inhibits tumor growth in glioma models, with enhanced efficacy when combined with temozolomide (TMZ) and no observed systemic toxicity.
- Findings suggest EGCG as a safe and promising adjuvant for glioma therapy, especially in combination with conventional chemotherapy.